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Search strategy This systematic review adhered to the guidelines employed the PICO(S) approach (Patient or Population, Intervention, Control or Comparison, Out- come, and Study types)

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doi: 10.1182/blood-2010-10-314427 260 MoleDRBlancherCCopleyRRPollardPJGleadleJMRagoussisJet al

Timeline: What to Expect Connective-tissue and skin effects in the underlying peptide literature are cumulative reported over weeks, not overnight

Research dose/evidence: A 2015 study found that application of topical GHKCu cream improved skin density, thickness, appearance, wrinkles, and pigmentation